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In the meta-analysis performed by Fox et al., several sources of bias were indicated which bring into question the validity of meditation studies which use neuroimaging. Fox et al. suggests a publication bias may be leading to the over-reporting of significant results.[18] Despite this, however, Fox et al. found "consistent differences in prefrontal cortex and body awareness regions" in "areas key to meta-awareness..., exteroceptive and interoceptive body awareness..., memory consolidation and reconsolidation..., self and emotion regulation..., and intra- and interhemispheric communication..." and that changes were significant with "moderate" global median effect size and "consistent and medium-sized brain structure differences."[18]
A more extensive study of over 100 participants who were undergoing general anesthesia for a day procedure, reported a decrease in pre-operative anxiety. The participants in this study listened to 30 minutes of binaural beats before surgery, but the researchers noted that people experiencing high levels of pre-operative anxiety could listen to binaural beats for up to 1 hour before anesthesia to reduce levels of anxiety.
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