The internal rhythm of the brain is called brainwaves and the brainwave pattern varies depending on what a person is doing – sleeping, relaxing, analyzing, etc. Brainwave entrainment is the response of the brain to stimulation with rhythmical sound, such as pulses or beats. After being stimulated with a certain frequency for a period of time, the brain reproduces the same frequency with its internal rhythm, thus achieving a targeted state.
I love your tapes! I bought them a few weeks ago and have greatly benefited. I’m also a holistic practitioner and have recommended them to a number of patients. And today when I made my last referral to your website for them to purchase from, it occurred to me that perhaps you have referral discounts, or wholesale prices for practitioners, and that I should ask?
Isochronic tones work just the same in delta as they do in alpha, theta and beta and they are widely used in the brainwave entrainment community to help people sleep. Like you, I’ve also seen some websites saying they don’t work in delta, but it’s a bit like the game of Chinese Whispers, where someone makes a comment and then after it gets passed around and shared a lot the message gets distorted and appears to be a fact. I don’t know of any scientific reason why they wouldn’t work in delta. I remember some people talking about this on a brainwave entrainment forum many years ago. They were saying they found isochronic tones a bit too abrupt for using to help them sleep and they preferred binaural beats, as they thought they were a more soothing sound. That was just a personal preference shared by a couple of prominent forum members at the time and some people then took that as a fact for everyone. That’s where I think that belief originated from.
Transparent Corp's Research Area is arguably the most comprehensive resource for collated brainwave entrainment research.   Update: the main research area on Transparent Corp's website is currently being updated, so it is offline.  However, you can still access their peer-reviewed research paper as a PDF here: “A Comprehensive Review of the Psychological Effects of Brainwave Entrainment“.

Robert Monroe, a radio producer and executive published a popular book called Journeys Out of the Body about his out-of-body experiences when using brainwave entrainment. He later founded an original brainwave entrainment audio company, Hemi Sync. In 1981, the book Mega Brain by Michael Hutchison brought brainwave entrainment information, techniques, and terminology into the popular press.

Effects on cortisol: The hormone cortisol is commonly associated with stress, and when levels are higher than usual, it can have a negative impact on the body. High levels of cortisol can lead to a range of conditions, including Cushing syndrome, menstrual cycle and female libido changes, anxiety, and depression. Dr. Giampapa noted a reduction of cortisol of up to 70-80 percent in several study participants.
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